What to Know About Ozempic, Wegovy, and Mounjaro Before Surgery

Medications like Ozempic, Wegovy, and Mounjaro (semaglutide and tirzepatide) are becoming increasingly common for managing type 2 diabetes and weight loss. If you are taking one of these medications and need surgery, it’s important to know how they may affect your anaesthetic care.

How Do These Medications Work?

These medicines belong to a class called GLP-1 receptor agonists (or dual GLP-1/GIP agonists for Mounjaro). They help regulate blood sugar and support weight loss by slowing down digestion and reducing appetite.

Because they slow the emptying of the stomach, they can increase the risk of nausea, vomiting, or aspiration (stomach contents entering the lungs) during anaesthesia.

What Are the Current Recommendations?

Fasting Requirements

To reduce risks during anaesthesia, patients taking these medications may be advised to:

  • Most patients should continue their medication unless your anaesthetist advises otherwise.
  • Follow a 24-hour clear fluid diet before surgery.

Other Considerations

Your anaesthetist may also take into account:

  • Whether you have other conditions affecting digestion.
  • What other medications you are taking.
  • Your overall health and surgical risks.

Key Takeaway

If you are taking Ozempic, Wegovy, or Mounjaro and need surgery, let your anaesthetist know. With proper planning — including tailored fasting instructions — you can have a safe anaesthetic and recovery.

References
ANZCA Clinical Practice Recommendations on GLP-1 receptor agonists.
ANZCA Patient Information Sheet on Preparing for Surgery While Taking These Medications.

 

Armadale Anaesthesia
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